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Horm Metab Res (1998) 30:2005

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Dual-Pathway Synergy Mechanistic Evidence Research in porcine models demonstrated that co-administration of a GHRH analogue with a GHSR agonist produced GH responses 24 times greater than either compound at equivalent doses, providing the pre-clinical mechanistic foundation for the combinations use in GH axis research

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Collectively, these studies highlight multiple pharmacological strategies to disrupt FSP1 function, including active-site inhibition, species-selective targeting and structure-guided inhibitor development