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No Significant Increase in Heart Failure Risk: Concerns regarding an increase in heart failure with saxagliptin, and to a lesser extent alogliptin, resulted in no use or cautious use of these agents in patients with cardiac backgrounds

For the 12 mg target, the escalation went through 2 mg, 4 mg, 6 mg, and 9 mg steps before reaching the full 12 mg dose

AOD 9604 wins on simplicity: no titration required, stable dose from day one

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Generally, corticosteroids are one of the first-line treatments