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Johnson WM, Wilson-Delfosse AL, Mieyal JJ

Factors such as acidosis and the use of central nervous system (CNS) stimulants and depressants can influence the CNS levels of lidocaine HCl and limit its efficacy

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This matters because glutathione exists in two states within your body, and the reduced form (GSH) represents the metabolically active version that actually performs anti oxidative stress functions