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In October 2025, Severe Gastrointestinal Adverse Reactions was added to the WARNING AND PRECAUTIONS section of the label

It leverages the proven benefits of semaglutide (a GLP-1 receptor agonist) and the innovative microneedle patch drug delivery system to supposedly offer an easy, non-invasive, and highly effective solution for major metabolic health concerns like obesity, diabetes, and heart disease

GLP-1 is a natural hormone, while semaglutide is a synthetic analog of GLP-1

The pharmaceutical company highlights that both primary endpoints were to demonstrate that oral Foundayo or Zepbound continuation at either the reduced dose or MTD was superior to placebo in maintaining body weight reduction

Gastrointestinal side effects such as nausea, vomiting, diarrhea, or constipation are common across GLP-1 therapies

Philippe K, Teo S, Perrotta C, McAuliffe FM, Phillips CM