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Greater doses provided greater weight loss and caused more side effects such as upset stomach and, in rare instances, dysesthesia (2.3%4.5% of those enrolled)

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Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels

either very low or very high adiposity impairs fertility

However, it's crucial to inform your healthcare provider about any heart conditions, as they may consider the specific risks and benefits of the medications for your situation