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however, these trials were discontinued due to lack of efficacy [16]
coli Nissle 1917 ( Ec N) to efficiently convert L-tyrosine, the substrate from which p-cresol, the precursor for the uremic toxin p-CS is derived from to p-coumaric acid which is a non-toxic compound via tyrosine ammonia lyase

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Tang N, Yuan S, Luo Y, Wang A-J, Sun K, Liu N-N, Tao K