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During the 36-week, open-label treatment period, 81.0% of individuals reported adverse events with gastrointestinal (GI) side effects being most common, including nausea (35.5%), diarrhea (21.1%), constipation (20.7%) and vomiting (16.4%)

As fibrotic scarring accumulates, nephron function declines irreversibly, underscoring the importance of targeting fibrosis as a central pathway in developing therapeutics for CKD