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Many patients notice that nausea, fatigue, or lightheadedness are more pronounced during the first few dose increases

Aim for 2 to 3 liters of water daily

Since GLP-1 acts on multiple pathways that are not fully addressed by other therapies, GLP-1 receptor agonists (drugs that mimic GLP-1 to improve insulin response and reduce glucose levels) have become the foundation for medications used in modern diabetes management 3

Whilst exendin-4-C16 showed minimal reduction in cAMP signalling potency, marked differences were observed for recruitment of key intracellular effectors and trafficking responses, which led to increased insulin secretion with prolonged incubations

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This led to the FDA approval of Mounjaro for type 2 diabetes and Zepbound for both type 2 diabetes and obesity, which are dual-action medications that mimic both GIP and GLP-1