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Medsafe finalized the details in May, leading the government to set a 3 July implementation date for the pathway

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Key gap: no human trial has been published, and no human pharmacokinetic study is widely available

Topical cream protocols Topical formulations allow targeted delivery to skin wounds, burns, and localized inflammation

Continuous use advantages include maintaining peak benefits without decline periods, avoiding the uncertainty of whether improvements will persist after breaks, simplifying routine through consistency, and potentially maximizing cumulative collagen synthesis through sustained stimulation over months to years

Skillbck et al