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In contrast, the pill may take a bit longer to show its appetite-suppressing effects, as it has to pass through the digestive system first

Two-thirds of weight regain after bariatric surgery can be safely lost with GLP1-RAs

Nausea occurs because semaglutide slows gastric emptying, meaning food stays in your stomach longer than usual, which can contribute to queasiness in some individuals

Musculoskeletal issues like weakened bones (osteoporosis), bone fractures, abnormal spine curvature (scoliosis, kyphosis) and hip malformation (dysplasia) Skin conditions like ulcers from blood pooling in the legs and skin infections (cellulitis)

However, in the long term, human mechanistic research is still needed