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Psychiatric manifestations of homocystinuria due to cystathionine synthase deficiency: prevalence, natural history, and relationship to neurologic impairment and vitamin B6responsiveness

Annals of the American Thoracic Society, 13 (Suppl 5), S422-S428

The second rationale relates to energy levels

Research on copper peptides has shown that even extremely low molar concentrations can trigger significant cellular responses were talking 10 to 10 M in laboratory settings [2]

J Biol Chem 2002

Hydroxocobalamin binds more tightly to serum proteins, creating a depot effect that allows for slower release and prolonged availability to tissues