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The N-terminus of the amylin peptide is predicted to form a loop, stabilized by a disulfide bond, that points out of the TM area, thereby tolerating N-terminal lipidation

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Subsequent subchronic dosing in HFD-fed mice revealed that Cagrilintide doses of 3 and 30 nmol/kg produced significant decreases in food intake during the first three days of treatment, but this effect waned over time

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