168 The control of this activity is regulated by USP13, which associates with gp78 and deubiquitinates Ubl4A, a process that optimizes PQC
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It gathers up these harmful substances and expels it from the body
10.1016/j.cgh.2023.06.004 92 ZhangN.LiuC.ZhangY.XuD.GuiL.LuY.et al (2021)
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For example, opioids decrease pulmonary perfusion via hypoxia-induced pulmonary vasoconstriction 143 , and by direct pulmonary vasoconstriction 144,145 by mechanisms including centrally-mediated activation of sympathetic nerve activity to the lungs 146 , and induction of histamine release in the lungs 144,147