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Accordingly, pharmacological inhibition of SLC7A11 or cysteine deprivation blocks GSH synthesis, leads to GSH depletion, and induces ferroptosis by disabling the antioxidant defense system 85,137

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Although CAT activity was inhibited following APP treatment, the T-AOC of serum was markedly enhanced

Multiple studies have indicated that the overexpression of GLS observed in many cancers may not only decrease glutamine levels but also elevate intratumoral glutamate levels [173, 174]