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To investigate the relationship for Hsp70, Hbs1, and Pns11, Sf9 cells were triply infected with the recombinant bacmids expressing Hsp70-His, Hbs1-Flag, and Pns11-Myc

As the disease advances, ferroptosis-induced release of damage-associated molecular patterns (DAMPs), exosomal transmission, and immune evasion mechanisms further amplify neuroinflammation and cell damage, establishing a cascade of intercellular pathological propagation that accelerates neurodegeneration

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Despite that the NMN bioavailability is evidenced by the rapid absorption and convention of administered NMN to NAD + in various organs, including skeletal muscle, kidney and liver, the transportation of NMN into cells remains unclear