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Mahani M, Bahmanpouri M, Khakbaz F, Divsar F
Your GP can perform a thorough assessment, review your complete medication list, and arrange appropriate investigations if needed
Since they activate the same receptor (GHSR-1a), combining them wouldn't produce the same synergy as pairing either with a GHRH analog (which uses a different receptor)
Presently the combination of a non-bile acid FXR agonist (GS-9674) + ACC inhibitor (GS-0976) is being investigated in an early phase II clinical trial.103 In an animal model of NASH, treatment with this combination therapy demonstrated a greater reduction in hepatic steatosis and genes associated with fibrosis than treatment with either agent alone.104 Future clinical trials will likely use combinations of agents that have already produced positive results individually
Heinrich, J.-C
We will also discuss the broader context of hormonal regulation and diabetes management to provide a comprehensive perspective on this topic
