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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores

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In skin, this can result in: Photodamage (premature aging) Hyperpigmentation Fine lines Lower collagen content Dull-looking skin As one of the master antioxidants throughout the body, glutathione wields the reparative powers to help suspend the process of accelerated oxidative stress and restore the appearance and function of healthy skin

Overall, IN DFO is expected to have a better safety profile than systemic high-dose DFO

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Autism is a neurodevelopmental disability that is usually diagnosed in the early years of life, often before age 3