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In head-to-head trials against semaglutide, the most potent available GLP-1 receptor agonist, tirzepatide demonstrated meaningfully greater improvements in both glycemic control and weight reduction
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Although Ozempic has demonstrated promise for weight management, its official approved indication remains controlling blood sugar levels in adults with type 2 diabetes
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PIONEER 5 and 8 also showed efficacy and safety of oral semaglutide as a second- and third-line drug.[15,16,17,18,19,20,21,22,30,31] Thus, oral semaglutide can be used across the spectrum of diabetes as a first-, second- and third-line drug
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