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In monkeys, sporadic abnormalities (vertebra, sternebra, ribs) occurred at clinically relevant exposures at the MRHD

Over a period of 4 to 8 weeks, as you move from the initial titration doses to higher therapeutic levels, the decrease in hunger becomes a steady state rather than a fluctuating feeling

And managing it matters, because uncontrolled burping can make social situations uncomfortable, disrupt sleep, and cause some people to abandon a medication that is otherwise working well for them

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The mean increase in clinical trials (at any visit) was one to four beats per minute, but 26% experienced an increase of 20 beats per minute or more