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have found in experiments on primary cortical neurons that SNPH also promotes the removal of damaged mitochondria in axons independently of mitophagy by creating vesicles with late-endosomes [48]

[PubMed] [Google Scholar] 78.Smyth EM, Grosser T, Wang M, Yu Y, FitzGerald GA

K.KumarD.SrivastavaA.et al (2016)

This observation hints that higher MOTS-c might correlate with better endothelial function, whereas a deficiency in MOTS-c could be linked to vascular problems

Yes, 3300mg is safe for healthy adults

The short half-life under 30 minutes means the peptide clears quickly, but its effects on gene expression and cellular signaling persist beyond this window