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It is produced naturally in every cell in the human body, with particularly high concentrations in the liver, where it plays a central role in detoxification

It is possible that the lower ghrelin levels in the obese may be a consequence of overconsumption, instead of the cause of the signal to other brain regions

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In addition, histidine deficiency could inhibit antioxidant capacity in largemouth bass intestines and induce gut endoplasmic reticulum stress, inflammatory responses, and apoptosis 35