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The amount in compounded tirzepatide (typically 0.5-1mg weekly) is well above the RDA but may not fully compensate for absorption issues and increased demands during rapid weight loss

Some effects, like BPC-157 GI protection, may become apparent sooner, while deeper immune changes from thymosin alpha-1 or selank may take longer to manifest

L.LevinD.MohanM.ForteathC.BeallC.et al (2016)

doi: 10.1016/S0891-5849(01)00640-2

The triggers of activating self-reactive clones are still to be determined, but may be common infections, molecular mimicry, or inflammation signals from gut microbiota (Westall, 2006)