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Importantly, these signals were completely abolished by PARPi treatment

Oxidative Medicine and Cellular Longevity, 2011 , 194586

Different pathways have been recently identified to play a key role in the escape of the immune system in senescence, highlighting the potential development of significant senolytic therapies in the future (Fig

Saupe M, Rauschenberger L, Preu M, Oswald S, Fussek S, Zimmermann U et al

pneumoniae , not only in the wt , but also in the gpoA, tpxD , and ahpD mutants, we used the same infection model for the A549 pneumocytes and RAW 264.7 macrophages, but with a treatment during infection of 5 mM NAC for 3 h for A549 cells, and 10 mM NAC for 1 h for RAW 264.7 cells

S., Kruh G