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Conflicts of Interest : There are no conflicts of interests REFERENCES ICH M10 on bioanalytical method validation - Scientific guideline European Medicines Agency (EMA) Xingbang Liu, Na Zhang, Xiaotong Gu, Yinhui Qin, Di Song, Long Zhang, Shutao Ma, Total Synthesis of Semaglutide Based on A Soluble Hydrophobic-Support-Assisted Liquid-Phase Synthetic Method, ACS Combinatorial Science, October 15, 2020