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In addition, sitagliptin (30 mg/kg/day) and exenatide (3 g/kg/12 h) significantly inhibited advanced glycation end products-induced oxidative stress in aortic endothelials in high fat diet (HFD)/STZ diabetic rats by reducing endothelin-1 (ET-1) and inflammatory cytokine via RhoA/Rho-associated protein kinase (ROCK)/NF- B signaling pathways and AMPK activation [67]