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A phase 3 trial found that high-dose oral semaglutide (50 mg) produced a 12.7% placebo-adjusted weight loss at week 68, comparable to subcutaneous semaglutide in patients without diabetes

A separate rapid review published in Obesity Reviews in late 2025 by Jebeile and colleagues, which analyzed 25 studies, found that binge eating episodes and prevalence were reduced following treatment with liraglutide and semaglutide

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In addition, c-Fos/AP-1 and IL-1 affect each others gene expression and activity to drive osteoclasts and interact with osteoclasts to promote joint destruction (216)

Additionally, weekly GLP-1RA users were more adherent to medication but less persistent than daily GLP-1RA users