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In 1956, 500 mg tablets went on sale in the United Kingdom under the trade name Panadol, advertised as being gentle to the stomach since other analgesics of the time contained aspirin, a known stomach irritant

Oral supplements require higher doses because only approximately 1% is absorbed passively when intrinsic factor is impaired, making injections the most reliable method for pernicious anaemia and malabsorption conditions

Abbreviations The following abbreviations are used in this manuscript: Author Contributions Conceptualization, A.d.G

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Reconstituted solutions: Keep refrigerated, protected from light, and use within a defined time window according to institutional laboratory practices and sterility controls

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