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Injection site reactions are more common with amylin analogs, and the dual-mechanism approach means managing two sets of potential adverse effects
These medications have high associated rebates, so employers should consider net cost rather than list price when evaluating economic impact of benefit design or management programs
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Phase 2 dose-escalation data showed mean weight loss of 24.2% at 48 weeks at the highest dose tested substantially exceeding semaglutide's 14.9% and approaching tirzepatide's 22.5% in comparable timeframes
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