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The diagnosis of 5-oxoprolinase deficiency is established by: Low activity of 5-oxoprolinase in nucleated cells such as leukocytes or cultured skin fibroblasts (5-oxoprolinase is not present in erythrocytes)

These are contraindicated during pregnancy due to teratogenicity risk

Benoist LB, van Looij MA

If you're experiencing significant gastrointestinal symptoms, your provider may extend this timeline or maintain your current dose longer

A healthcare professional will then review the information before deciding whether the medication is suitable to prescribe

Several circuits adopted the scope of the patent test: as long as the settlement did not extend the generics exclusion beyond the patents own expiration date, the settlement was presumptively legal under the logic that a patent holder should be able to settle within the scope of the rights the patent grants