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While DKA is rare with GLP-1 receptor agonists, cases have been reported, particularly when concomitant insulin is rapidly reduced or discontinued

While the evidence is promising, it shouldn't be viewed as a miracle ingredient

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These should be: Individualised : Starting at a low intensity and gradually increasing to avoid symptom flare-ups

(2018, PLOS ONE ): transdermal dihydroberberine (a chemically modified form) applied in a pharmaceutical-grade cream with penetration enhancers achieved roughly 7x higher bioavailability than oral berberine in rats

Drucker the 2020 Warren Alpert Foundation Prize