The receptors targeted by each drugthe PPAR- receptor and the GLP-1 receptor, respectivelyare widely distributed in numerous tissues with as yet ill-defined roles
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These individuals include: Allergy or hypersensitivity to GLP-1 medications Type 1 diabetes Pancreatitis Gastroparesis Medullary thyroid cancer Multiple endocrine neoplasia type 2 or family history of these conditions Pregnant, nursing, or trying to become pregnant Individuals with renal impairment Active eating disorder or history of disordered eating As always, the decision to use GLP-1s should be made in consultation with a healthcare professional who can assess an individual's medical history and overall health to determine if the medication is suitable for them
Molecular weight 711.85 Da
Pros and cons of GLP-1 medications Many people on GLP-1 drugs lose a significant amount of weight
It has never been FDA-approved as a drug for any indication, and the absence of a completed phase III trial program means rare, long-term adverse events (including any cancer signal) may not yet be fully characterized in the way they would be for an approved compound
