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USP18 induction regulates immunometabolism to attenuate M1 signal-polarized macrophages and enhance IL-4-polarized macrophages in systemic lupus erythematosus

Interestingly, there was also a substantial reduction in HbA 1c in the semaglutide group (9.88 mmol/mol [0.90%-points]), which is surprising, given that the trial participants had all been receiving treatment with a GLP-1 RA

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Abbreviations ARNI, angiotensin receptor neprylisin inhibitor

The STEP trials demonstrated that semaglutide produces sustained weight loss of 15-22% of initial body weight over 68 weeks, significantly exceeding results from traditional non-GLP-1 medications