It tends to be dose-dependent and is more prominent during aggressive titration
For reference, the FDA label dose of tesamorelin alone is 2 mg/day (legacy formulation) or 1.28 mg/day for the newer EGRIFTA WR formulation, and ipamorelin has been studied at roughly 100-300 mcg per dose in research settings
doi: 10.1042/bsr20231918 3 BallW
For more than two decades, researchers pursued the goal of delivering GLP-1 receptor activation through an oral tablet, a pursuit complicated by the fundamental biochemistry of peptide drugs: their vulnerability to acid hydrolysis in the stomach, enzymatic degradation in the gastrointestinal tract, and poor absorption across the intestinal epithelium
7.2.3 Drugs that have both the capacity to enhance radiosensitivity and to attenuate radiation damage In addition to the aforementioned agents, there are other drugs with similar mechanisms of action
The goal is to give you an honest picture so you can decide, with your provider, whether its worth your time