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[36] [37] In January 2026, the US Food and Drug Administration requested removal of a suicidal behavior and ideation warning from GLP-1 receptor agonist medications

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As new therapies emerge, clinicians face a critical question: which modern therapy offers the best outcomesGLP-1 agonists or SGLT2 inhibitors

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Finally, another layer of complexity is added when considering the evidence of a leaky bloodbrain barrier across several neuropsychiatric disorders 255 , which could further increase the brain penetrance of GLP-1RAs administered to people with such illnesses

GLP-1 is a natural hormone made by the intestine