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The VDR gene is placed on chromosome 12q12 and is expressed by many immune cells, especially dendritic cells

It is incorporated into selenoproteins that protect cells from oxidative damage, support normal muscle and heart function, and maintain healthy immune and thyroid activity

PCa incidence per 10,000 patient-years in cohorts 1 and 2 was 54.4 and 30.7, respectively, which is lower than 116 reported by the PLCO (Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial) and 96.6 reported by the ERSPC ( European Randomized Study of Screening for Prostate Cancer)

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the cuprizone (CPZ) mice were given 0.2% cuprizone w/w for 12 weeks