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[54] and, more recently, Nylander et al

The majority of primary liver cancers are hepatocellular carcinomas (HCC), accounting for 75% to 85% of cases ( In nonalcoholic fatty liver disease (NAFLD)-associated HCC, cancer cells show an elevated expression of N 6 -methyladenosine (m6A)-methyltransferase catalytic subunit (METTL3)

Practical management strategies include: Cycle tracking: Use a menstrual diary or smartphone application to document cycle length, flow characteristics, and associated symptoms Nutritional adequacy: Ensure sufficient caloric intake to support metabolic health despite weight loss goals

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