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Patients should disclose a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, kidney disease or dehydration risk, use of diabetes medications such as insulin or sulfonylureas, pregnancy or plans for pregnancy, any personal or family history of medullary thyroid carcinoma or MEN2, and a history of diabetic retinopathy

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To reduce bruising, avoid areas with visible veins, do not rub the site after injection, and make sure you are rotating sites weekly

20.2% mean weight loss at max tolerated dose over 72 weeks in SURMOUNT-5 head-to-head vs

Because retatrutide is unlicensed, it is not routinely prescribable through NHS or standard private prescribing routes in the UK

Liraglutide users without diabetes showed higher chances of delayed gastric emptying (139%) and ileus (32%) compared to other weight loss medications