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Weight is determined primarily by biology and genetics, not by willpower alone. But taking anti-obesity medications isnt the easy way out, said Rekha B

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Last reviewed: July 17, 2026 Last updated: July 17, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

This hypermetabolic state paradoxically makes weight loss difficult despite increased calorie burning, because the body's regulatory systems become dysregulated