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On further probing Madsen found that the tumours secreted an abundance of GLP-1, which he published in a paper together with Holst and others in 1995 (Blume, Skouv, Larson)

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Though a protease/anti-protease balance is less well studied in periodontal disease, it makes sense to consider this process in a disease where loss of collagen in connective tissue is pathognomic and there is a body of evidence to support it as a key pathological process