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Heart failure was not clearly defined in trials protocols, left ventricular ejection fraction was reported only in EXSCEL trial and in 4 trials heart failure functional class was defined

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Lifestyle and pregnancy loss in a contemporary cohort of women recruited before conception: the LIFE Study

Data from the PIONEER (Peptide Innovation for Oral Delivery of Semaglutide in Type 2 Diabetes) trials (NCT03018028 and NCT03015220) indicated that oral semaglutide also led to dose-dependent weight loss in both younger and older adult groups, but body composition was not assessed [57]

But it is the most disproportionately associated with semaglutide specifically

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