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Both peptides show systemic bioactivity but act most strongly at sites of injury or inflammation

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As a more severe procedure, chronic unpredictable stress (after 5 d of unpredictable stress protocol, once daily drug application during stress procedure, open field-immobility test assessment at fourth or sixth day of medication) was used

low initial dosage and careful monitoring may avoid this risk

Mechanism Overview BPC-157 increases growth factors (VEGF, FGF), FAK-paxillin signaling, and also changes the pathways of nitric oxide

Each freeze-thaw cycle creates ice crystals that can physically disrupt peptide structure, and the process concentrates the peptide at the boundary between frozen and unfrozen regions, potentially causing aggregation