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Formal safety data specific to topical AHK-Cu is limited, and theoretical concerns such as copper accumulation with heavy long-term use have not been characterized in human studies

Effects of creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin A pilot clinical, histologic, and ultrastructural study

Piibor J, Waldmann A, Dissanayake K, et al

Priya Nair Clinical Pharmacist & Senior Drug Information Specialist | 9 years Pharm.D

Published safety data from clinical trials report no significant adverse effects across all studied doses and durations

Allergy 32 , 489498 (2002)