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These were individuals who lost 10% or more of their body weight by week 16

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Oxidative stress is the natural wear and tear caused by free radicalsunstable molecules that can damage your DNA and cell membranes

10 Based on the high prevalence of MTHFR genetic polymorphisms in the general population and concerns about reduced enzymatic activity and, therefore, less biologically available l-methylfolate, newer research in this area has focused on supplementation with l-methylfolate rather than folic acid as a means of preventing folate-related pathology

2011 Jun;17(6):PI15-23