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Even changing the environment being either in a warm environment, cold environment, calming environment, stressful

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Moreover, existing evidence demonstrated that inhibiting the phosphorylation of PI3K could increase AQP4 expression, which suggested that PI3K/Akt involves in the regulation of AQP4 (Song et al., 2018)

The monitoring protocol remains the same, but the interpretation of results and dose adjustment decisions require specialized expertise