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Over recent years, multiple studies have indicated that the use of glucagon-like peptide 1 (GLP-1) can cause an increased risk of gallbladder disease

36,37 In two of the aforementioned trials, researchers reported changes in each of the 11 symptoms on the MRS: women taking the Siberian rhubarb extract in these trials experienced significant reductions in all 11 items on the MRS after 12 weeks compared with those taking placebo.35,36 In a follow-up study, 80 of the initial 109 participants were given the same dose of the extract for 48 weeks of observation, and 51 continued treatment for an additional 48 weeks

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The Downside: What Happens When You Stop