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doi: 10.1111/j.1365-2265.2011.04008.x

Tirzepatide (with Pyridoxine) : Tirzepatide is a dual agonist at GIP and GLP1 receptors, originally developed for type 2 diabetes, and is now widely used for significant, clinically meaningful weight loss and metabolic health improvements

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Sensitivity analysis To ensure that any short-term outcomes in the GLP-1 agonists or control groups were not due to chronic high-risk factors not accounted for in PSM, we performed a sensitivity analysis by performing the same analysis listed above and excluding outcomes within 1 year after the index event

It does have some very nice properties indeed, though famous dermatologist Leslie Baumann warns us in her book that most of the evidence is anecdotal and the plant might be a bit overhyped