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As the cases of chronic diabetic wounds have become a major burden in recent times

hence, it can be recommended as adjuvant therapy alongside MTX to counteract its cytotoxic adverse effects

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The commenters also shared their belief that the proposed cost category weighting could lead clinicians to avoid managing complex, high-acuity patients, and avoid resource-intensive but clinically appropriate settings like hospitals (including rural and critical access facilities)

Initially, it was considered an effective anti-tumor mechanism