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More serious B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes

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So at least in my case, and again, this is anecdata, it seemed to

And this isn't some rare, obscure issue

Inflammation Control as a Prerequisite for Tissue Quality KPV has demonstrated potent suppression of inflammatory mediators such as TNF- and IL-6, which are implicated in connective tissue degradation, impaired regeneration, gut barrier dysfunction, and inflammatory contributions to skin aging