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The 1.5-3x baseline IGF-1 elevation in trial reports is the pharmacologic mechanism, not an adverse event per se but it informs the monitoring pattern community sources commonly describe

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A plateau is defined as three weeks or more without a loss in body weight or body fat

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Risk may increase in certain clinical or physiological situations associated with disturbances in transport, balance or carnitine losses, whether due to genetics or other clinical conditions

doi: 10.1210/jc.2008-0115 162 ChuffaLGLupi JniorLAda Maia LimaAF