Importantly though, the study also identified a range of potential health risks associated with the use of GLP-1 drugs
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Gut Microbiome Findings There was a mean 31.4% increase in the relative abundance of Akkermansia muciniphila , 35.4% increase in Faecalibacterium prausnitzii , 24.8% increase in Coprococcus eutectus , and 48.7% increase in Roseburia faecis at week 10 compared to baseline (Figure 5)
The dual pathway approach appears to produce a more comprehensive effect on hunger and satiety signalling than targeting either receptor alone